A study that is not Exempt may often be appropriate for Expedited Review, in which the Committee Chairperson or a Committee member designated by the Chair carries out the review. Such research includes all noninvasive medical research and all non-medical research on humans, provided that research is found by the reviewer to involve no more than minimal risk (i.e., the "probability and magnitude of harm or discomfort anticipated in the research are not greater in and of themselves than those ordinarily encountered in daily life or during the performance of routine physical or psychological examinations or tests," §46.102(i)). All animal research is also subject to Expedited Review. Minor changes to previously approved research are also subject to Expedited Review.
Under an Expedited Review, the reviewer may only approve the research, require modifications in the research (no further review necessary once modifications are made), or refer the research to a full (non-expedited) review (i.e., the reviewer may not disapprove the research). All Expedited Reviews will be carried out anonymously (i.e., the person submitting the application should not know which Committee member is reviewing the application).